Unlocking the hidden power of blood flow data

By applying robotics and artificial intelligence to cerebral ultrasound, NovaSignal uniquely captures blood flow data in real time. The new NovaGuide™ 2 Platform empowers the clinical team with critical, real-time information about cerebral blood flow to guide diagnosis and improve patient outcomes.

What’s New

Introducing the NovaGuide 2 Intelligent Ultrasound. With cutting-edge AI and advanced robotics, NovaGuide 2 makes complex cerebral assessments easy. Learn more >

Introducing NovaGuide View. A revolutionary way to improve patient care, NovaGuide View enables faster time to treatment with on-demand access to dynamic exam data.
Learn more >

Blood Flow in the Brain
is Indicative of Overall Health

Access to real-time data can prevent disability or death. With more than 200 clinical studies published annually, indications for the use of cerebral ultrasound are expanding.

  • Cerebral Vasospasm
  • Cerebral Aneurysm
  • Cerebral Edema
  • Intracranial Bleeding
  • Intra & Extracranial Stenosis
  • Ischemic Stroke
  • Patent Foramen Ovale
  • Pulmonary Shunt
  • Traumatic Brain Injury
  • Brain Death
  • Internal Carotid Artery Disease
  • Atherosclerosis of Intracranial Vessels
  • Sickle Cell Disease
  • Moyamoya
  • Cerebral Vasoreactivity
  • Perfusion
  • Emboli


The prevalence of PFO among the cryptogenic stroke population is ~40% to 50%.1

With 96% sensitivity and 92% specificity, TCD has been shown to detect 2X the number of PFOs vs TTE.2


Vasospasm has been reported in as many as 70% of patients after a subarachnoid hemorrhage.3

Guidelines recommend using TCD to monitor for the development of arterial vasospasm.4

Intraprocedural Monitoring

It is estimated that every year up to 600,000 patients in the U.S. suffer a stroke during, or after, a cardiovascular procedure.5

TCD monitoringis now recognized as a practical tool to detect intra‐ and periprocedural events.6

Introducing the

NovaGuide™ 2 Platform

A comprehensive solution designed to seamlessly integrate into existing clinical practice. The NovaGuide 2 Platform empowers the clinical team with critical information about cerebral blood flow to guide diagnosis and improve patient outcomes.

NovaGuide View

Providing secure, cloud-based access to dynamic exam data, NovaGuide View is a critical piece of the overall patient assessment.

NovaGuide 2

With cutting-edge AI and advanced robotics, the NovaGuide 2 Intelligent Ultrasound uniquely captures blood flow data in real-time to identify brain illnesses and diseases that present as changes in cerebral blood flow.

NovaKit 2

NovaKit 2 provides required essentials to ensure exams are safe, comfortable, and personalized for each patient.


NovaCare provides certified service and support for NovaGuide systems, including 24/7 remote support, on-site servicing, loaner devices, and more.


NovaSignal is committed to advancing patient care through innovative, evidence-based solutions for patients and providers.

Physician Perspectives

Dr. Alan B. Lumsden

“Integrating the NovaGuide gives clinicians a chance to look inside the brain at blood flow patterns in real time and rapidly identify physiological changes associated with neurological disorders, enabling efficient diagnosis and triage for treatment.”

Dr. Alan B. Lumsden
Medical Director and Chair of Cardiovascular Surgery
Houston Methodist DeBakey Heart and Vascular Center

Dr. Alex Reynolds

“It is remarkable that a diagnostic machine used to study the brain could give us insight into the pathophysiology of a pulmonary disease. The benefit of using this particular system was that automated monitoring allowed providers to assess cerebral blood flow while minimizing the potential for exposure to COVID-19.”

Dr. Alex Reynolds
Neurocritical Intensivist and Asst Professor of Neurology
Icahn School of Medicine at Mount Sinai

“NovaSignal’s solution, including the automated ultrasound and cloud application, provide unsurpassed access and accuracy for cryptogenic stroke management and PFO assessment.”

Dr. Andrei V. Alexandrov
Semmes-Murphey Professor and Chairman of Neurology
University of Tennessee Memphis

FDA-cleared robotic
ultrasound technology

NovaSignal is committed to providing safe and effective solutions for assessing brain health that adhere to all statutory and regulatory requirements. Our products meet FDA regulations, ISO 13485:2016 standards, and MDSAP requirements for quality management systems.

Find out more

For immediate service needs, call 1 (877) 638-7251 ext. 3

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