Evidence and Research

We are committed to advancing brain
health through innovative, evidence-based
solutions for patients and providers.

Evidence & ResearchEvidence & Research

Over 130 peer-reviewed citations
covering NovaSignal’s technology

Read some examples of this groundbreaking research

J Clinical Neuroscience
September 2020

A Review of the Use of Transcranial Doppler Waveform Morphology for Acute Stroke Assessment

Review article >
American Journal of Respiratory and Critical Care Med (AJRCCM)
August 2020

Pulmonary Vascular Dilatation Detected by Automated Transcranial Doppler in COVID-19 Pneumonia

Manuscript >
American Journal of Respiratory and Critical Care Med (AJRCCM)
August 2020

Bubble Trouble in COVID-19

Letter to the Editor >
Journal of Neurocritical Care
June 2020

Robotically assisted transcranial Doppler with artificial intelligence for assessment of cerebral vasospasm after subarachnoid hemorrhage

Manuscript >
Fluids and Barriers of the CNS
June 2020

Review: pathophysiology of intracranial hypertension and noninvasive intracranial pressure monitoring

Review article >
Neurology and Neurosurgery
April 2020

Feasibility study in the combination of non-contrast computed tomography and transcranial Doppler for large vessel occlusion detection

Original research article >
PLoS One
January 2020

Towards Automated Classification of Pathological Transcranial Doppler Waveform Morphology via Spectral Clustering.

Original research article >
Frontiers In Neurology
September 2019

Algorithm for Reliable Detection of Pulse Onsets in Cerebral Blood Flow Velocity Signals

Original research article >
BioMed Research International
June 2019

Identification of Pulse Onset on Cerebral Blood Flow Velocity Waveforms: A Comparative Study

Review article >
IEEE Transactions on Biomedical Engineering
June 2019

Objective Assessment of Beat Quality in Transcranial Doppler Measurement of Blood Flow Velocity in Cerebral Arteries

Original research article >
Frontiers in Neurology
May 2019

Sex-Based Differences in Transcranial Doppler Ultrasound and Self-Reported Symptoms After Mild Traumatic Brain Injury

Original research article >
J Concussion
February 2019

A model of longitudinal hemodynamic alterations after mild traumatic brain injury in adolescents

Original research article >
Fluids and Barriers of the CNS
January 2019

Opposing CSF hydrodynamic trends found in the cerebral aqueduct and prepontine cistern following shunt treatment in patients with normal pressure hydrocephalus

Original research article >
Translational Stroke
September 2018

Velocity Curvature Index: a Novel Diagnostic Biomarker for Large Vessel Occlusion

Original research article >
Frontiers in Neurology
September 2018

Decision Criteria for Large Vessel Occlusion Using Transcranial Doppler Waveform Morphology

Original research article >
Frontiers In Neurology
March 2018

A Cross-Sectional Study on Cerebral Hemodynamics After Mild Traumatic Brain Injury in a Pediatric Population

Original research article >
Biomedical Signal Processing and Control
March 2016

Noise reduction in intracranial pressure signal using causal shape manifolds

Original research article >
Med Eng Phys
October 2013

Intracranial Hypertension Prediction using Extremely Randomized Decision Trees

Original research article >
IEEE Trans Biomed Eng
October 2013

Noninvasive Intracranial Hypertension Detection Utilizing Semi-Supervised Learning

Original research article >
PLoS One
October 2012

Continuous Detection of Cerebral Vasodilatation and Vasoconstriction Using Intracranial Pulse Morphological Template Matching

Original research article >
J Appl. Physiol.
September 2012

Intracranial pressure pulse waveform correlates with aqueductal cerebrospinal fluid stroke volume

Original research article >
Neurocrit Care
November 2010

Inter-Subject Correlation Exists Between Morphological Metrics of Cerebral Blood Flow Velocity and Intracranial Pressure Pulses

Original research article >
Neurocrit Care
October 2010

Consistent Changes in Intracranial Pressure Waveform Morphology Induced by Acute Hypercapnic Cerebral Vasodilatation

Original research article >
J Neurosci Methods
July 2010

Pattern Recognition of Overnight Intracranial Pressure Slow Waves using Morphological Features of Intracranial Pressure Pulse

Original research article >

We’ve been awarded over $25M in research
grants from the DoD, NIH, and NSF

NovaSignal Clinical Trials

Large Vessel Occlusion
Cerebral Blood Flow Velocity Morphology – Large Vessel Occlusion
Completed
Objective
To collect adequate quality data to develop an algorithmic framework for assessing cerebral vascular occlusions confirmed by standard of care Computer Tomography Angiography (CTA) imaging.
Design
Prospective, multi-center, multi-arm, multi-cohort
Number of Subjects
147
Traumatic Brain Injury
Advanced Morphological Analysis of Cerebral Blood Flow for Acute Concussion Diagnosis and Return-To-Play Determination.
Completed
Objective
To develop and evaluate an analytical platform for quantifying cerebral hemodynamic dysfunction following mild TBI and expand our medical and scientific understanding of these changes.
Design
Prospective, longitudinal, single-center, multi-arm, multi-cohort
Number of Subjects
219
Intracranial Bleed
Precision Intracranial Bleed Triage and Monitoring
Enrolling
Objective
To determine if cerebral hemodynamic dysfunction can be used to rapidly classify traumatic brain injury and determine if the subject(s) are at risk of deteriorating.
Design
Prospective, multi-arm, multicenter, non-invasive
Number of Subjects
Up to 600
Intracranial Pressure
Cerebral Blood Flow Velocity Morphology for Quantification of Intracranial Pressure
Enrolling
Objective
To collect high quality cerebral blood flow velocity (CBFV) measurements to develop an algorithmic framework to determine correlation to and estimates of intracranial pressure when measured with invasive monitoring.
Design
Prospective, multi-center, multi cohort, non-invasive
Number of Subjects
Up to 540
PFO
NovaGuide Intelligent Ultrasound Compared to Transthoracic Echocardiography for Detection of Right-to-Left Shunt
Enrolling
Objective
To evaluate the shunt detection rate of the NovaGuide Intelligent Ultrasound relative to standard of care diagnostic techniques (TTE, TEE, SOC TCD), and to assess the safety, accuracy and usability of the device.
Design
Prospective, single-arm multicenter, non-significant risk
Number of Subjects
Up to 150